COMPARATIVE REVIEW OF ANTISECRETORY & MUCOSAL PROTECTIVE DRUGS FOR NSAID RELATED GI COMPLICATIONS

Preeti Khulbe*, Birendra Shrivastava, Pankaj Sharma and Ajay Kumar Tiwari

ABSTRACT

Non-steroidal anti-inflammatory drugs have been used most widely in many diseases. Despite of many therapeutic effects the use of NSAIDs has also been associated with cardiovascular (CV), renal, and gastrointestinal (GI) complications. In which GI complications are most common. GI complications are generally mediated through inhibition of mucosal cyclooxygenase-1 (COX-1) primarily and suppression of prostaglandin production. According to literature H. pylori and NSAIDs are the two most common causes of peptic ulceration. Many agents have been used in treatment and prophylaxis of GI complications such as mucosal protective agents, antisecretory drugs, antibiotics and probiotics, food constituent etc. Majorly used drugs for NSAIDs related GI complications are PPIs, H2RA and misoprostol. In this article a comparison has been made between these three categories of drugs. This article also covers the comparison on the basis of cost, pregnancy etc. As per review it can be concluded that PPIs are superior then H2RA and Misoprostol because of high efficacy in ulcer treatment, Long lasting effect of drug, potency, healing ulcer also in case of continuous NSAID therapy. Although PPIs are more effective than H2RAs, some patients can be switched to H2RAs are remain satisfied with their treatment.

Keywords: Gastrointestinal complications, antisecretory drugs, food constituent, PPIs, H2RA, misoprostol.