EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARATIVE REVIEW OF ANTISECRETORY & MUCOSAL PROTECTIVE DRUGS FOR NSAID RELATED GI COMPLICATIONS

Preeti Khulbe*, Birendra Shrivastava, Pankaj Sharma and Ajay Kumar Tiwari

ABSTRACT

Non-steroidal anti-inflammatory drugs have been used most widely in many diseases. Despite of many therapeutic effects the use of NSAIDs has also been associated with cardiovascular (CV), renal, and gastrointestinal (GI) complications. In which GI complications are most common. GI complications are generally mediated through inhibition of mucosal cyclooxygenase-1 (COX-1) primarily and suppression of prostaglandin production. According to literature H. pylori and NSAIDs are the two most common causes of peptic ulceration. Many agents have been used in treatment and prophylaxis of GI complications such as mucosal protective agents, antisecretory drugs, antibiotics and probiotics, food constituent etc. Majorly used drugs for NSAIDs related GI complications are PPIs, H2RA and misoprostol. In this article a comparison has been made between these three categories of drugs. This article also covers the comparison on the basis of cost, pregnancy etc. As per review it can be concluded that PPIs are superior then H2RA and Misoprostol because of high efficacy in ulcer treatment, Long lasting effect of drug, potency, healing ulcer also in case of continuous NSAID therapy. Although PPIs are more effective than H2RAs, some patients can be switched to H2RAs are remain satisfied with their treatment.

Keywords: Gastrointestinal complications, antisecretory drugs, food constituent, PPIs, H2RA, misoprostol.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia