A REVIEW ON CALIBRATION OF PHARMACEUTICAL INSTRUMENTS

Sejal Pokale*, Shamal Adokar, Shravani Inkane

ABSTRACT

The present study focuses on the calibration and verification of in-house laboratory equipment, including the pH meter, weighing balance, and UV-visible spectrophotometer, in accordance with Good Manufacturing Practice (GMP) standards and relevant Pharmacopoeial requirements. Accurate and reliable analytical measurements are critical in pharmaceutical and research laboratories, and periodic calibration ensures data integrity, traceability, and compliance with regulatory guidelines. The pH meter was calibrated using standard buffer solutions at pH 4.00, 7.00, and 9.20 under controlled temperature conditions. The weighing balance was verified for accuracy, repeatability, linearity, and eccentricity using certified standard weights, confirming proper performance for routine analytical weighing. The UV-visible spectrophotometer was calibrated. All performance parameters were found to comply with the specified limits. The outcome of this study confirms that all three instruments are fit for routine analytical use, maintain compliance with GMP standards, and provide reliable and reproducible results.

Keywords: Calibration, weighing balance, pH meter, UV spectrophotometer.