CORRELATION BETWEEN PROPERTIES OF MUCOSA OF RECTUM AND EFFICACY OF MATRA BASTI WITH TILL TAIL:
*Vd. Sachin Sonappa Dargu, Vd. Suryakant Dattatray Rokade, Vd.Chandrashekhar Dattatray Vaikos, Vd. Manisha Kishanrao Dawre, Vd. Prashant Gopinath Sali and Vd. Pradnya Ravindra Deshpande
Rectal route delivery is an efficient alternate to oral and parenteral route in partial avoidance to first pass metabolism. In Ayurveda, panchkarma therapy is usually carried out for samsodhan and samsaman. This therapy includes vaman, virechan, basti, nasya, raktmokshan. Basti karma includes niruha (shodhan) and anuvasana (saman). Classical literature attaches a great significance to this form of treatment. Anuvasan basti includes Matra basti in which there is use of till tail in single or medicated form. Anuvasan basti has no harmful effect even if staying in body. Rectum has sub mucosal fold called valves of Houston. Has no villa, epithelium layer is one cell thick, composed of cylindrical and goblet cells which secrets mucus. Absorption of drugs from epithelium involves transcellular route depends on lipophilicity. Intestinal absorption of fatty acids depends on the partition coefficient. Efficacy of Anuvasana basti definitely depends on its local action. For that purpose one should know the affinity of fatty acids present in till tail towards the mucus membrane of intestine. The present work is done to study the factors affecting the affinity of fatty acids with respect to structure of mucosa of intestine.
Keywords: Pakwashaya, Vata dosha, Anuvasana Basti, Mucosa of rectum-1) Partition Coefficient 2) Absorption barrier, Fatty acids in White till tail.
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