“DEVELOPMENT AND EVALUATION OF BILOSOMAL GEL LOADED WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUG”

Renuka N., Rama Bukka*, Shachindra L. N., Shravan L. Nargund, H. Kirana, Nidhi Malviya

ABSTRACT

The study focused on developing and optimizing a Diclofenac sodium bilosomal gel for enhanced topical delivery and sustained anti-inflammatory action. Bilosomes were prepared using the thin film hydration method using soya lecithin, cholesterol, Span 60, and bile salts, Sodium deoxycholate [SDC] / Sodium Tauroglycocholate [STGC] were tried using 32 Factorial design and optimized using Design Expert Software (version 13.5). Among 18 [9+9] formulations, SDC-based bilosomes showed superior results, with spherical vesicles (138–310 nm), high entrapment efficiency (84–90%), and sustained drug release up to 12 hours following zero-order kinetics and non-Fickian diffusion. The optimized formulation incorporated into a Carbopol-934 gel demonstrated acceptable pH, viscosity, and drug content, releasing 80.63% of the drug over 12 hours. Ex vivo studies confirmed better skin permeability for bilosomal formulation compared to Diclofenac sodium bilosomal gel and marketed products, indicating that bilosomal gel offers a promising system for effective and sustained topical delivery of Diclofenac sodium.

Keywords: Bilosomes; Diclofenac sodium; Sodium deoxycholate (SDC); Sodium tauroglycocholate; Skin permeation; Carbopol-934 gel; In vitro drug release; Ex-vivo studies.