FORMULATION, OPTIMIZATION AND EVALUATION OF CELECOXIB LOADED CUBOSOME FOR TOPICAL DRUG DELIVERY SYSTEM

M. Sujitha, Sriram M.

ABSTRACT

The present study is mainly focused to formulate the celecoxib loaded cubosomes. Celecoxib is [NSAID] medication used to treatment of pain and inflammation, associate with rheumatoid arthritis, and several other inflammatory disorder. Celecoxib shows poor solubility and poor bioavailability, to overcome the problems, Celecoxib is formulated as cubosomal gel. Pre-formulation studies were carried out, in this FTIR study results indicate there is no chemical interaction between drug and excipients. Eight different formulations (F1- F8) were prepared by Top -Down technique. Among the eight formulations, formulation (F7) was optimized, because of its high Entrapment efficiency (88.2%) and maximum percentage of drug release (89.69%) at the end of 8hrs compared to other formulations. The average particle size of cubosomal gel (F7) was found to be 488.21nm. The SEM images represent cubosomal gel (F7) are cubic in shape. From the In- vitro kinetics studies Formulation (F7) fitted with Higuchi release kinetics. Stability studies indicate that the cubosomal gel (F7) were stable during stability studies. Celecoxib loaded cubosomal gel may improve the bioavailability and solubility, So The celecoxib is suitable for the formulation of cubosomal gel.

Keywords: Celecoxib, cubosomes, GMO, Poloxamer 407, Top- Down technique, Bioavailability, solubility.