PHOTODYNAMIC THERAPY IN POTENTIALLY MALIGNANT DISORDERS -A NARRATIVE REVIEW

Sneha V*, Dr. Sindhu Poovannan, Dr. G. S. Asokan, Dr. Narmatha N.,  Dr. Angelinteena S.

ABSTRACT

Photodynamic therapy has emerged as an innovative and conservative approach in managing oral potentially malignant disorders. Photodynamic therapy (PDT) involves three key components: a photosensitizer, a specific wavelength light source, and molecular oxygen present within cells. The interaction among these elements leads to the destruction of proteins, lipids, nucleic acids, and other cellular components in diseased tissues. This review highlights the mechanism, elements, different phases, advantages and limitations of photodynamic therapy and how effectively employed either as a standalone treatment or as an adjunctive modality, based on evidence from published literature. Additionally, it offers a comprehensive overview of PDT and its therapeutic applications in managing oral diseases.

Keywords: Photodynamic therapy; Oral potentially malignant disorders; adjunctive modality.