IN VITRO EVALUATION OF ANTIMICROBIAL POTENTIAL OF ANTHROCEPHALUS CADAMBA (Roxb) FLOWER EXTRACT

Sneha Rani*, Mrs. Shaily Mishra, Dr. Shamim Ahmad

ABSTRACT

The Kadam tree is highly regarded as religiously and culturally in India being sacred to Lord Krishna, and hence, the tree is also known as Haripriya, God’s favourite. In this article investigated “In vitro evaluation of antimicrobial potential of Anthrocephalus cadamba (Roxb) Flower Extract’’. Antidiabetic, antioxidant, antitumor, nephrotoxic, diuretic and laxative, antihepatotoxic, hypolipidemic, analgesic, antipyretic, anti-inflammatory, anti-filarial, antimalarial, sedative, antiepileptic, immunomodulatory, antivenom, gastro-protective, anthelminthic, wound healing, and antimicrobial properties are just a few of its pharmacological activities. The plant Antherocephalus Cadamba, which is a member of the "family Rubiaceae," is frequently used to treat these kinds of illnesses. Triterpenes, triterpenoid glycosides, flavonoids, saponins, and indole alkaloids—cadambine, cadamine, isocadambine, and isodihydrocadambine are the plant's main ingredients. In this study, the antibacterial activities are suggested by “Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Aspergillus Niger”. Extract produced significant inhibition zones (11–16 mm) against test pathogens. MIC ranged from 50–100 mg/mL, and time-kill studies confirmed bactericidal nature. >65% efficacy compared to standard antibiotics observed in S. aureus, C. albicans. Results are statistically significant and aligned with traditional therapeutic use.

Keywords: Anthrocephalus Cadamba, Bioactive constituents, Cadambin, Haripriya, Antimicrobial properties.