EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

STRONTIUM RANELATE AS A NEW TREATMENT OF KNEE OSTEOARTHRITIS INDUCED BY MONOSODIUM IODOACETATE IN ALBINO RATS

Sanaa A. Ahmed* and Hekmat O. Abdel-Aziz

ABSTRACT

Objective: To evaluate the efficacy and the possible mechanism of action of strontium ranelate (SR) in the treatment of knee OA induced by monosodium iodoacetate (MIA) as a new indication of this drug, also, to detect whether cartilage oligomeric matrix protein (COMP) is a reliable biomarker that can facilitate the diagnosis of osteoarthritis (OA). Methods: twenty-four adult male Swiss albino rats weighing 150–200 g were assigned randomly into 4 groups, 6 rats in each: group I (control group), group II (SR-treated group), group III (MIA-induced OA) and group IV (MIA-induced OA + SR). Weights, knee diameters, knee bend scores were recorded on days 0, 1, 7, 14 and 28. On day 29 all animals were sacrificed, blood samples and synovial fluid of knee joints were collected; cartilage oligomeric matrix protein (COMP), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) levels were measured. The knee joints were removed and stained with H&E and Masson trichrome stains for histopathological and effect on collagen fibers evaluation. Results: Serum and synovial fluid levels of COMP, MDA, knee diameter and knee bend score were increased while SOD and CAT activities decreased in MIA-induced OA group associated with histopathological changes of OA. SR succeeded in amelioration of these parameters and preserve normal joint architecture compared to MIA-induced OA group. Conclusions: Higher serum and synovial COMP, however, reduction in antioxidant enzyme levels in MIA-induced OA. SR can ameliorate not only the antioxidant scavenging enzymes, but also pathological cartilage degradation, and can be considered as an effective drug in the management of knee OA.

Keywords: Antioxidant enzymes, Cartilage oligomeric matrix protein, MDA, Osteoarthritis; Strontium ranelate, Monosodium iodoacetate.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )