STERILIZATION OF BONE ALLOGRAFTS IN THE BONE BANK, AHMEDABAD: A SYSTEMATIC REVIEW AND ITS EFFECTS

Sakchi Bhushan*, Jagdish Gulabrai Buch

ABSTRACT

There is an increased requirement for bone substitutes in orthopaedic applications, spinal fusion, dental applications and craniofacial reconstruction surgeries. Bone allografts are used to repair bone tissue due to their excellent osteoconductivity and ease of availability. Still, the transmission of infectious disease from the donor tissue is an aspect influencing its assurance. Therefore, bone allografts should be sterilized for safe implantation in the recipient to achieve better clinical outcomes. This review summarizes the importance of sterilization and its types, advantages, and disadvantages. In addition to that, for the commercialization of bone allografts, the association of medically approved sterilization techniques is of vital importance. Overall, we summarize the review in which the use of chemical sterilants followed by physical radiation as terminal sterilization in The Bone Bank is well discussed.

Keywords: Bone allografts, Infectious diseases, Chemical sterilants, Physical agents, Terminal sterilization.