BIOENHANCERS IN HERBAL MEDICINES

Kante Pallavi*, P. Sailaja, Y. Prapurnachandra

ABSTRACT

Bioenhancers are natural compounds that enhance the bioavailability and therapeutic efficacy of drugs and nutrients without exerting significant pharmacological activity of their own. In herbal medicine, bioenhancers play a crucial role in improving the absorption, Metabolism, and utilization of active phytoconstituents, Thereby maximizing therapeutic outcomes. Traditionally, Several plant-derived compounds such as piperine (from Piper nigrum), Quercetin, Curcumin, Gingerols, And glycyrrhizin have been identified as potent bioenhancers. Their mechanisms include modulation of drug-metabolizing enzymes (such as CYP450), Inhibition of P-glycoprotein efflux transporters, Enhancement of gastrointestinal absorption, And alteration of cell membrane dynamics. The use of bioenhancers is particularly valuable in herbal formulations, where poor solubility, Instability, Or low permeability often limit the effectiveness of phytochemicals. Combining bioenhancers with herbal actives not only increases their pharmacokinetic performance but also allows for dose reduction, Minimizes adverse effects, And promotes synergistic therapeutic actions. Recent advancements in nanotechnology and pharmacognosy have further facilitated the design of novel herbal formulations incorporating bioenhancers for improved delivery and efficacy. Moreover, bioenhancers have shown promising applications in enhancing the effectiveness of conventional drugs, Highlighting their potential in integrative medicine. However, more clinical research is needed to fully understand their safety profiles, long-term effects, And standardization in formulations. Overall, Bioenhancers represent a significant innovation in herbal therapeutics, Bridging the gap between traditional knowledge and modern drug delivery systems to achieve optimized pharmacological benefits.

Keywords: Synergistic effect, Integrative medicine, Trikatu, Drug availability.