SPHINGOSOME: A NOVEL VESICULAR DRUG DELIVERY SYSYTEM
Abhijeet Sunder Kunwarpuriya*, VishakhaVishwanath Doke, Suchita Changedia,
Nilesh Mahadeo Khutle
Sphingosomes are bilayered vesicles in which an aqueous volume is entirely enclosed by membrane lipid bilayer mainly composed of sphingolipids. It overcomes disadvantages of liposome, noisome and other vesicular drug delivery system. Sphingosomes are stable to acid hydrolysis and have better drug retention characteristics. They are mostly used for chemotherapy because various size and composition of sphingolipids. They are basically liposomal formulation based on sphingomyelin based cholesterol has several advantages when compared to other formulation. This review gives an idea about Sphingosomes as a promising vesicular drug delivery system to deliver therapeutic compound for all possible application.
Keywords: Vesicular system, sphingolipids, Sphingosomes, sphingomyelin.
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