FORMULATION AND EVALUTION ORAL BUCCAL PATCH

S. J. Wadaskar*, S. S. Warhade, Dr. A. D. Kajale

ABSTRACT

Buccal route offer attractive route of administration for systemic drug delivery. Mucoadhesive Buccal Patch of Losartan potassium was prepared by using carbopol(grade 934,940), Sodium CMC. Losartan potassium (angiotensin II receptor blockers) which works by relaxing blood vessels. The polymeric film was composed of different proportions of sodium carboxymethylcellulose (Na CMC), Carbopol and prepared by solvent casting method. Glycerol was used as plasticizer. Carbopol 934 provide taste masking functionality in case of bitter taste. six formulation were prepared with varying concentration of carbopol and carboxymethylcellulose and evaluated for various parameter like weight variation, patch thickness, folding endurance, surface pH, drug content uniformity. The surface PH was found to be in range of saliva PH. Increase in concentration of Carbopol was found to be increase in the mucoadhesive strength. Based on the evaluation of these result it was concluded that the buccal patches of Na CMC and CP-934(800:400) showed moderate drug release for 6 hrs. Data of in vitro release from patches were fit to different equations and kinetic model to explain release mechanism.

Keywords: Buccal patch, Mucoadhesiv, losartan potassium.