RISK FACTORS AND EARLY MARKERS OF PRIMARY IMMUNODEFICIENCIES IN PEDIATRIC PRACTICE

Matkarimova A. A.*, Jiemuratova G. K., Seitimbetova B. Z., Kurbanbaeva R. U., Tursinbekova N. K.

ABSTRACT

The article presents an analytical review of contemporary national and international data on the risk factors and early diagnostic markers of primary immunodeficiencies (PID) in children. It discusses genetic, epigenetic, and environmental factors influencing the development of congenital defects of the immune system, as well as the clinical and immunological characteristics that make it possible to suspect immune deficiency at early stages. The importance of timely identification of patients with PID in pediatric practice is emphasized, as it plays a crucial role in preventing severe infectious and autoimmune complications.

Keywords: Primary Immunodeficiencies, children, risk factors, early markers, immune status, diagnostics.