FORMULATION AND EVALUATION OF NATURACEUTICAL ALOE INERMIS EXTRACT FOR WOUND HEALING ACTIVITY AS ANTIBACTERIAL CREAM NOVEL DRUG DELIVERY SYSTEMS

Prof. Dr. Mahmoud Mahyoob Alburyhi*, Prof. Dr. Bushra Moharram

ABSTRACT

Aloe inermis is a non-African species native to western Yemen and grow in dry stone hills at around 1000-2000 m in elevation. Aloe inermis belongs to family Aloeacea and is used traditionally in skin care for burns, rashes, allergic irritation, wounds and infections. According to previous study that reported the wound healing activity of Aloe inermis latex. In the current study, the dry latex of Aloe inermis was formulated in seven formulations to study the variant characteristics of cream. The present study is aimed to formulate the methanolic extract into a suitable herbal cream and evaluate for its physiochemical, and stability parameters. Among the seven formulations (F1-F7), F7 showed good spreadability, good consistency, homogeneity, appearance, pH; there is no proof of a separation phase and ease of washability. The compositions of formulation F7 were Aloe inermis extract, Cetomacrogol, Cetostearyl alcohol, Liquid paraffin, white soft paraffin, Propylene glycol, Cholorocresol, Beeswax, Sodium dihydrogen phosphate, Titanium dioxide, Lavender oil, Methylparaben, and Purified water. It was concluded that the best formulation selected F7 was safe in respect to natural herb offer diverse benefits in cream preparations, as evidenced by this study, highlighting the safety compared to commercial semisolid products. The study showed that the extract of Aloe inermis could be used as an alternative for wound healing activity as cream NDDS formulation.

Keywords: Aloe inermis, Cream Formulation, Antimicrobial agent, Wound Healing Activity, Novel Drug Delivery Systems.