SYNTHESIS AND EVALUATION OF NOVEL ISATIN DERIVATIVES FOR ANTIMICROBIAL ACTIVITY

Dr. M. Rajasekaran*, K. Kiran Kumar, P. Madhumitha, R. Kaviya Priya, S. Kavya Priya, M. Krishnamoorthy

ABSTRACT

This study details the synthesis of 1-benzyl indoline-2,3-dione and its derivatives through a series of chemical reactions, followed by their characterization and evaluation of biological activities. The method starts with the reaction of indoline-2,3-dione with benzyl chloride, leading to 1-benzyl indoline-2,3-dione, which undergoes further transformations to form ethyl 2-(1-benzyl-2-oxoindolin-3-ylidene)acetate and acetohydrazide derivatives. These compounds were characterized by their physical properties, melting points, and solubility profiles, with further analysis through Thin Layer Chromatography (TLC), IR, and NMR spectroscopy. The biological activity of the synthesized compounds was evaluated for antibacterial and antifungal properties, revealing significant inhibition against various pathogens. These results indicate the potential of these compounds as bioactive agents, with compound B showing promising antimicrobial effects.

Keywords: 1-benzyl indoline-2,3-dione, acetohydrazide derivatives, antimicrobial activity, antibacterial, antifungal, NMR, IR spectroscopy.