EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN (O) : 2394-3211

 ISSN (P) : 3051-2573

Impact Factor: 7.065

 ICV - 79.57

Abstract

DUAL DRUG-LOADED NIOSOMAL GEL OF LICOFELONE AND SPIRAMYCIN: FORMULATION AND EVALUATION

Manish Singh, Shruti Shukla, Shivam Sushil, Ajay Singh, Ankur Srivastava, Ajay Kumar Verma*

ABSTRACT

The present study focused on the development and evaluation of a dual drug-loaded niosomal gel for the topical delivery of Licofelone and Spiramycin. The optimized formulation (F5) exhibited a particle size of 136.7 ± 8.37 nm, a low polydispersity index (PDI) of 0.316 ± 0.92, and a zeta potential of –20.9 mV, indicating uniformity and good colloidal stability. Entrapment efficiency was found to be 70.8 ± 0.55%, attributed to the optimal balance of surfactant and cholesterol concentration. Transmission electron microscopy (TEM) confirmed spherical vesicle morphology with no aggregation. In vitro drug release studies showed a sustained release pattern, achieving 94.19% cumulative release over 24 hours, compared to 26.25% release from the plain gel. Rheological characterization revealed a viscosity of 11,924 ± 1.051 cp and spreadability of 3.6 ± 0.256 cm, allowing for effective topical application and retention. Pharmacodynamic evaluation using the carrageenan-induced paw edema model demonstrated 95.7% inhibition of edema at 24 h when the formulation was applied 12 hours after induction, surpassing the marketed diclofenac gel, which achieved 93.5% inhibition. Stability studies over 90 days indicated excellent stability at 2–8 °C, with particle size changing minimally from 137.5 ± 0.436 nm to 139.9 ± 0.963 nm, while room temperature led to greater instability. Skin irritation studies confirmed no erythema or allergic reaction. Overall, the dual drug-loaded niosomal gel exhibited sustained release, enhanced anti-inflammatory activity, favorable rheological properties, excellent stability, and dermal safety, positioning it as a promising future platform for effective and patient-compliant topical therapy in inflammatory and infectious skin disorders.

Keywords: Niosomal gel, Dual drug delivery, Sustained release, Anti-inflammatory, Stability, Topical therapy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia Doi-Digital Online Identifier ISSN National Centre Zenodo Indexing International CODEN Service, USA

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