EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN (O) : 2394-3211

 ISSN (P) : 3051-2573

Impact Factor: 7.065

 ICV - 79.57

Abstract

IN VITRO ANTI-INFLAMMATORY, IN SILICO MOLECULAR DOCKING ANALYSIS, AND PHYLOGENETIC ANALYSIS OF CURCUMA NEILGHERRENSIS

M. Krishnaveni, Selvi Sellappan*, G. Rubalakshmi

ABSTRACT

Background: Plants not only supply vital nutrients for people, but also contain physiologically active phytochemicals that are advantageous for human life and the management of several ailments. The herbal plants are regarded as a treasured reservoir of possible anti-inflammatory phytochemicals. Objective: The present work was focused at analyzing the in vitro anti-inflammatory properties and in silico analysis of the saponins extracted from the Curcuma neilgherrensis roots. Methodology: The total saponins were extracted from the root extract of C. neilgherrensis. The anti-inflammatory effectiveness of the total saponins from the roots of C. neilgherrensis was examined by albumin denaturation inhibition analysis and membrane stabilization analysis. In silico studies and phylogenetic studies were done to detect the protein components responsible for the therapeutic effects of C. neilgherrensis, including cytochrome c oxidase subunit 1, ribulose bisphosphate carboxylase large chain, maturase K, and ATP synthase subunit 1. Results: The total saponins obtained from the roots of C. neilgherrensis demonstrated an effective anti-inflammatory properties in vitro, which is evidenced by its inhibitory effects on albumin denaturation and HRBC membrane stabilization. The findings of an in silico molecular docking analysis and phylogenetic analysis demonstrated the possible roles of cytochrome c oxidase subunit 1, ribulose bisphosphate carboxylase large chain, maturase K, and ATP synthase subunit 1 protein molecules in the therapeutic effects of the saponins extracted from C. neilgherrensis roots. Conclusion: The present study demonstrated that the total saponins extracted from the roots of C. neilgherrensis revealed an encouraging anti-inflammatory potentials. Thus, it was clear that C. neilgherrensis has the capacity to be beneficial in treating diseases related to inflammation in the future.

Keywords: Inflammation, Curcuma neilgherrensis, Molecular docking, Maturase K, Membrane stabilization.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia Doi-Digital Online Identifier ISSN National Centre Zenodo Indexing International CODEN Service, USA

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