EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , Doi-Digital Online Identifier , ISSN National Centre , Zenodo Indexing , International CODEN Service, USA , 

 ISSN (O) : 2394-3211

 ISSN (P) : 3051-2573

Impact Factor: 7.065

 ICV - 79.57

Abstract

GENOTOX?C?TY/CARC?NOGEN?C?TY OF BENZYL-PARABEN ON F?SH (SPARUS AURATA) US?NG M?CRONUCLEUS ASSAY

Özlem Çakal Arslana*, Beyza Nalbantlar, Gizem Gulsevera, Muhammet Ali Karaaslana, Koray Benasa

ABSTRACT

Parabens are widely utilized as preservatives in an array of consumer products. During the lifecycle of these productsparabens such as benzylparaben (BeP) are released into the environment. In this study investigating the genotoxic effects of BeP on Sparus aurata, we are employed the micronucleus assay—a wellestablished method for evaluating DNA damage at cellular levels. Fishs are exposed to varying concentrations of BeP (0.2 μg/L to 1 μg/L). The findings revealed significant increases in MN frequencies across different tissues; specifically, blood cells exhibited a frequency of 26.4 ‰ at the highest concentration tested, while gill cells showed an alarming frequency of 41‰ and liver cells recorded 33 ‰. These results underscore that exposure to benzylparaben induces genotoxic effects in S. aurata, highlighting its potential risk not only for marine life but also for ecosystems where such substances may accumulate through various pathways.

Keywords: Micronucleus assay, Genotoxicity, Sparus aurata, Benzylparaben.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia Doi-Digital Online Identifier ISSN National Centre Zenodo Indexing International CODEN Service, USA

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