COMPARATIVE IN VITRO RELEASE STUDIES OF DUAL ENCAPSULATION TECHNOLOGY (DELT) BERBERINE WITH CONVENTIONAL LIPOSOMAL BERBERINE AND UNFORMULATED BERBERINE

Sreya E. S.*, Jenish M. John, Nandu Bhaskar A. V., Manus Varghese N. J.

ABSTRACT

Berberine Hydrochloride (BRN) is poor water soluble alkaloid, used in various traditional medicinal practices. Liposomal BRN formulations have higher oral absorption due to higher solubility but they have low physical and chemical stability. So Dual Encapsulation Technology (DELT) based liposomal BRN is an advanced liposomal technology in which the plant proteins are used to make a surface coating of normal liposomes to get additional stability. In this study we compared the in vitro release of DELT-BRN with conventional liposomal BRN and unformulated BRN. The results showed that DELT-BRN has better release in comparison with conventional liposomal BRN and unformulated BRN.

Keywords: Liposomal Berberine; DELT Berberine; in vitro release; Dialysis membrane.