EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

COMPARATIVE STUDY BETWEEN DKK-1 AND AFP FOR DIAGNOSING OF HEPATOCELLULAR CARCINOMA AMONG EGYPTIAN PATIENTS.

Faten Zahran Mohamed, LamiaaAbdullateef Ali Barakat, Noha Hassan Radwan and Mohsen Mohamed Mohamed Khedr*

ABSTRACT

Background: Hepatocellular carcinoma is a major health problem. It was ranked 2nd most common cancer site among males and 7th among females. AFP is the main routinely parameter for HCC diagnosis, it can also be elevated in liver cirrhosis. It represents a liver cell- specific, not a tumor-specific marker, for these reasons, our suggestion is to use AFP as a supplementary marker for diagnosis of HCC. So identification of sensitive biomarkers to improve early diagnosis of HCC is needed. Our aim is to evaluate serum Dickkopf-1 (DKK1) as biomarkers for early diagnosis of HCC. Methods: The study included 40 HCCs patients (stage I (9) cases, stage II (31) cases), 30 liver cirrhosis patients, and 20 healthy subjects were enrolled. Serum DKK1 using ELISA kit was measured in all included subjects. Results: Serum DKK1 was significantly elevated in HCC group compared to cirrhotic and healthy control groups. Receiver operating characteristic curve showed the best cutoff values for DKK1, and AFP were (1 ng/ml and 400 ng/ml) respectively. Area under the curve of DKK1 was significantly larger than that of AFP (0.990 vs. 0.763). The sensitivity of DKK1 and AFP was (98% vs. 28%) respectively. Conclusion: Serum DKK1 might be potential diagnostic markers for HCC.

Keywords: HCC patients, DKK1, AFP.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia