COMPATIBILITY STUDIES OF PYRIMETHAMINE WITH PHARMACEUTICAL EXCIPIENTS FOR THE DEVELOPMENT OF SUPPOSITORIES NOVEL DRUG DELIVERY SYSTEMS

Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman, Abdalwali Ahmed Saif

ABSTRACT

The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Pyrimethamine antimalarial drugs in formulated suppositories Drug Delivery Systems. Pyrimethamine is classified as a biopharmaceutics classification system (BCS) Class-I. Preformulation, formulation and evaluation of Pyrimethamine to avoid problems associated with conventional delivery system such as limited permeation, low dissolution and bioavailability and also to improve bioavailability and one of the most antimalarial agents. In the present study that the compatibility was assessed by, FTIR spectroscopy, and melting point apparatus, precompression parameters. Results showed that physical mixtures of antimalarial and various excipients as PEG4000 base, Cocoa butter and Witepsol H35 were evaluated for preformulation studies parameters. It was concluded that the drug Pyrimethamine was found to be compatible with various excipients which were selected for the formulation development of the Pyrimethamine antimalarial drug in formulated suppositories Drug Delivery Systems. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.

Keywords: Pyrimethamine, Compatibility, Suppositories, Preformulation, Formulation, Antimalarial drug.