EFFICACY AND SAFETY OF KESHOHILLS TABLET IN MILD TO MODERATE HAIR FALL: AN OPEN-LABEL CLINICAL STUDY

Ajitkumar Mandlecha* and Gous Shaukatali Mujawar

ABSTRACT

Background: Hair fall (―Khalitya‖ in Ayurveda) is a common condition influenced by lifestyle, diet, stress, systemic diseases, and environmental factors. Ayurvedic herbal formulations are traditionally used for hair health. Keshohills tablet is a polyherbal formulation containing botanicals with reputed benefits for hair growth, scalp health, and dandruff reduction. Objective: To evaluate the efficacy and safety of Keshohills tablet in adults with mild to moderate hair fall. Methods: This open-label, single-arm, clinical trial enrolled 35 participants aged 21–45 years with active hair fall. Participants received Keshohills tablets orally for 60 days. Primary endpoints included hair fall reduction (60-Second Hair Comb Test) and dandruff improvement (Adherent Scalp Flaking Score, ASFS). Secondary endpoints included changes in scalp itching and safety assessments. Evaluations were conducted at baseline, Day 15, Day 30, Day 45, and Day 60. Data were analyzed using statistical test. Results: Keshohills tablet significantly reduced mean hair fall from 2.67 ± 0.48 to 1.00 ± 0.00 (p < 0.0001; 62.5% improvement). ASFS scores decreased from 5.51 ± 1.71 to 0.18 ± 0.58 (p < 0.0001; 96.8% improvement). Scalp itching reduced by 100% by Day 60, with the majority of improvement observed by Day 45. No adverse events were reported. Conclusion: Keshohills tablet was well tolerated and effective in reducing hair fall, dandruff, and scalp itching in participants with mild to moderate hair fall. Early resolution of itching suggests anti-inflammatory and scalp-conditioning properties preceding hair retention benefits.

Keywords: Alopecia, Hair fall, Dandruff, Ayurveda, Keshohills tablet.