SAUSSUREA COSTUS A PLANT USEFUL IN AVERTING BREAST CANCER PROGRESSION: AN OVERVIEW

Chandra Shekhar Sharma*, Mansi Sharma, Rudramani Tiwari, Om Prakash, Vivek Kumar, Divya Kumari, Ajay Kumar Meena

ABSTRACT

In the post COVID era, among the many incidences reported two are significant; increased cases reported for breast cancer and signifying the role of Ayurveda and natural medicine in modern era. There are difficulties in managing breast cancer overall when taking into account risk assessment, predictive diagnostics, focused prevention of metastatic disease, suitable treatment options, and the cost-effectiveness of implemented strategies. In this scenario indigenous plant based medication is a good option. Saussurea costus (Falc.) Lipschitz, syn Saussurea lappa C.B. Clarke, root has two important phytochemicals viz. Costunolide and Dehydrocostus lactone. These two compounds have been reported for their application in breast cancer treatment, in isolation as well as in combination. In present review we have confined in compilation of all the previously reported work showing effectiveness of these two compounds on the basis of their inhibitory concentration (IC50) on different cell lining (MCF-7, MDA-MB-231, MDA-MB-468, MDA-MB-453, etc.) for breast cancer; also different path through which it helps in averting the progression of breast cancer metastasis. Some recent reports shown evidences of application of MgO, Pd nanoparticles also. The outcome of all these discussions indicates that present compounds have great potential in developing lead NCEs (New Chemical Entities) in treatment of breast cancer.

Keywords: Saussurea costus, Costunolides, Dehydrocostus lactone, Breast cancer, Apoptosis.