FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE SOLID SELF-MICROEMULSIFYING SYSTEM TRANSNASAL DELIVERY SYSTEM

Deepti Bajpai Dubey*, Saravanan K.

ABSTRACT

The current study set out to create an S-SMEDDS of OXZ to improve the drug's solubility and stability in the final product. Sodium starch glycolate was employed as the adsorbent in the adsorption to solid carrier technique since it was needed in amounts ranging from 0.5 to 0.95 grammes to transform 1 millilitre of L-SMEDDS into a free-flowing powder. The 9OSF1-S, 9OSF2-S, 9OSF3-S, 9OSF4-S, and 9OSF5-S Out of all the prepared S-SMEDDS powders, 5RSF1-S, 5RSF2-S, 5RSF3-S, 5RSF4-S, and 5RSF5-S demonstrated superior flow properties. Using the proper ratio of sodium starch glycolate to LSMEDDS, ten S-SMEDDS formulations were created. In vitro dissolution studies revealed that 9OSF4-S and 5RSF3-S, two of the eight S-SMEDDS formulations, had the best flow characteristics and the highest drug release when compared to pure drug. Because 9OSF4-S and 5RSF3-S had the best and highest results from the in vitro dissolving investigation, they were chosen for more research. In the case of 5RSF3-S, the particle size and zeta potential were 164.24 nm and - 13.9 mv, respectively, but in the case of 9OSF4-S, they were 78.13 nm and - 21.5 mv. For both S-SMEDDS formulations, 9OSF4-S and 5RSF3-S, an accelerated stability study (40 ± 2 °C/75 ± 5% RH) and a real-time stability study (25 ± 2 °C/60 ± 5% RH) were conducted. All of the findings show that the current study's stated objective of increasing permeability—aside from bioavailability—of the weakly soluble medication oxcarbazepine through improved drug solubility was effectively achieved.

Keywords: Self-Microemulsifying System, Nasal Delivery System, Oxcarbazepine,