FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE LIQUID SELF-MICROEMULSIFYING SYSTEM TRANSNASAL DELIVERY SYSTEM

Deepti Bajpai Dubey*, Saravanan K.

ABSTRACT

The objective of the study was the development and in vitro characterization of a liquid self-emulsifying drug delivery system (L-SMEDDS) for the nasal application of oxcarbazepine. Final composition of L-SMEDDS was established based on drug solubility and stability studies. Oxcarbazepine's self micro emulsifying drug delivery system (SMEDDS) was made with excipients including oil, cosurfactant, and surfactant Nine formulations from each of the 18 L-SMEDDS formulations were subjected to a thermodynamic stability analysis, which included centrifugation, the heating and cooling process, and the freeze-thaw stress cycle. L-SMEDDS from the 'OSF' formulation batch were identified as OSF6, OSF7, OSF8, and OSF9 based on the results of a thermodynamic stability investigation. Drug content analysis suggested that the formulations OSF9 and RSF5 have highest percentage of drug content i.e. 91.54 ± 2.29% and 88.91 ± 2.76%. According to the droplet size analysis, in the case of OSF L-SMEDDS formulation batch, OSF9 was found to have the smallest average droplet size, 193.2nm and in case of PF L-SMEDDS formulation batch, the average droplet size of RSF5 was found to be 276.3nmRSF2, RSF3, RSF4, and RSF5 shown thermodynamic stability in the 'RSF' formulation batch. The formulations OSF9 and RSF5 showed the maximum release rate of all the L-SMEDDS formulations in the case of the 'OSF' and 'RSF' formulation batch, with 87.23±2.76% w/w and 85.11±2.65% w/w in 210 minutes, respectively. All the results indicate that the proposed goal of the current research work of improving permeability other than bioavailability of oxcarbazepine, a poorly soluble drug, by improving drug solubility was met successfully.

Keywords: Nasal route, Micro-emulsion, L-SMEDDS, Oxcarbazepine.