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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57



Hernández-Ramírez María de los Angeles, Maldonado-Bernal Carmen, Hernández-Calleros Jorge, Gómez-Quiroz Luis Enrique, Martínez-Benítez Braulio, Alfaro-Lara Roberto, Barbero-Becerra Varenka J, Gutiérrez-Ruiz María Concepcion,*, Vargas-Vóracková Florencia,†


Helicobacter pylori (Hp) and non-steroidal anti-inflammatory drugs(NSAID) are the major causes of gastric-disorders. Oral GABA-treatment down-regulates inflammatory-responses in rheumatoid-arthritis (RA) models. We investigate the anti-inflammatory effect of oral-ingestion of GABOB in dyspeptic-patients with RA and NSAID intake to establish if Hp-colonization contributes to the association between NSAID and peptic damage. 26 patients with RA who took NSAIDs and dyspeptic-symptoms were recruited. Patients were tested for Hp-infection. TNF-α, TGF-α, TGF-β, IL-10, IL-8, NO expression and secretion were determined in antrum-duodenum biopsy and plasma before-after GABOB-treatment. Immohistochemistry and Sydney evaluation were also conducted. Severity of dyspepsia assessment (SODA) test was applied. Ten patients were Hp+ and 16 Hp-. IL-8 expression presented higher-values in antrum from patients Hp+, and it correlated with greater inflammatory-infiltration. Data didn´t show significant changes in cytokine-levels as a result of GABOB, except IL-8 secretion that increased in Hp+ duodenum biopsy. Moreover, it was observed an increase of Smad3 expression in Hp- duodenum and a decrease in TGF-β plasma-levels in the same patients. Apparently, Hp colonization doesn´t contribute to increased damage, since we didn´t find any correlation among dose, NSAID type, time consuming and gastropathy. These findings suggest that GABOB-treatment improves dyspepsia-tolerability at 60% and 69% of Hp+ and Hp- patients. However, 4 weeks of GABOB-treatment didn´t improved inflammatory-mediators in gastric-biopsies nor in plasma-levels.

Keywords: cytokines, antrum, duodenum, Sydney evaluation, SODA test.

[Full Text Article]



  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 November 2021 Issue has been Published, Kindly check it on


    NOVEMBER Issue has been successfully launched on 1 November 2021.

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    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )