EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , Doi-Digital Online Identifier , ISSN National Centre ,

ISSN (O) : 2394-3211

ISSN (P) : 3051-2573

Impact Factor: 7.065

ICV - 79.57

Abstract

PITOLISANT HCl: A REVIEW ON DRUG CHARACTERISTICS AND COMPARATIVE HPLC METHOD DEVELOPMENT AND VALIDATION

Vignesh J.*, Murugan S. and Vetrichelvan T.

ABSTRACT

Pitolisant, a selective histamine H3 receptor antagonist/inverse agonist, is an innovative therapeutic agent for treating narcolepsy and related disorders of excessive daytime sleepiness. The review focuses on the development and validation of high-performance liquid chromatography methods and analysis of pitolisant in pharmaceutical formulations and bulk, critical aspects of HPLC method development, including the selection of mobile phase, stationary phase, flow rate and detection parameters, are examined to achieve optimal separation and sensitivity. This work aims to provide a comprehensive resource for researchers and analysts to ensure the quality control and regulatory compliance of pitolisant, contributing to its therapeutic efficacy and safety in clinical applications.

Keywords: Pitolisant, HPLC, Method development, validation.

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SJIF Impact Factor: 7.065

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	All	Since 2019
Citation	3086	2560
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New Issue Published
Its Our pleasure to inform you that, EJPMR 1 August 2025 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR: AUGUST ISSUE PUBLISHED
AUGUST 2025 issue has been successfully launched on 1 AUGUST 2025.

EJPMR New Impact Factor
EJPMR Impact Factor has been Increased to 7.065 for Year 2024.

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EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

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EUROPEAN JOURNAL OF PHARMACEUTICAL AND MEDICAL RESEARCH