EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

THE EFFECT OF PARTIAL PURIFIED PLANTARICIN AGAINST URINARY TRACT INFECTION (UTI) INDUCED BY ESCHERICHIA COLI AND PROTEUS MIRABILIS IN EXPERIMENTAL RAT MODEL

*Rana Hussein Raheema and Abdul Karim Salim Mahood

ABSTRACT

The present study was purposed to assess the effect of plantaricin of L. plantarum in vivo by inducing uti in rats with Escherichia coli and Proteus mirabilis and to check out its effect on some biochemical and histopathological parameters. Fifty four rats were divided into five groups, Group (A): negative control (not infected group), Group (B): positive control (infected E. coli, P. mirabilis respectively and not treated group) for 2,5 and 10 days, Group (C): Animals were administrated orally 160 AU / ml of plantaricin for 14 days then infected with E.coli and P. mirabilis for 2,5 and 10 days, Group (D): infected with E.coli, P. mirabilis respectively and treated orally with 160 AU / ml of plantaricin for 14 days and Group (E): infected with E.coli and P. mirabilis respectively and treated with gentamicin 2 mg /ml. B.W.I.M for 14 day. At the end of experimental period, blood samples were taken to estimate the biochemical measurements such as serum creatinine and uric acid. Results showed an elevation of serum creatinine level in infected group with Escherichia coli and P. mirabilis compared with normal group. Result showed significant changes in serum uric acid and creatinine in infected and treated groups. Histological sections of kidney showed severe damage in infected groups compared with treated groups. It could be concluded that plantaricin of L. plantarum has potent protective role against UTI and appears by correction between biochemical parameters and histological studies.

Keywords: L. plantarum, E. coli, P. mirabilis.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database