ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR VALACYCLOVIR HYDROCHLORIDE

Bhavya K. B.*, Divyashree M. P., Chethana K. S. and Sachin V.

ABSTRACT

Analytical method development and Validation are the continuous and inter-dependent task associated with the research & development, quality control and quality assurance departments. Literature survey reveals that the analytical methods based on UV spectrometry, and HPLC for the determination of Valacyclovir. The developed methods are simple, sensitive and reproducible and can be used for the analysis of Valacyclovir in bulk and Tablet dosage form. Valacyclovir hydrochloride, an antiviral prodrug of acyclovir, is widely used in the treatment of herpes simplex and varicella-zoster infection. The results demonstrated that the proposed UV spectroscopic method is suitable for routine analysis of valacyclovir in quality control laboratories due to its simplicity, cost-effectiveness, and reliability.

Keywords: Valacyclovir, UV Visible Spectrometer, Validation of the method was performed following ICH guidelines.