AN OVERVIEW OF POLMACOXIB AND ITS DIFFERENT ANALYTICAL METHOD

Indhumathi K.*, Murugan S. and Vetrichelvan T.

ABSTRACT

Polmacoxib is a novel nonsteroidal anti-inflammatory drug (NSAID). As an NSAID, it belongs to a class of drugs commonly used to alleviate symptoms associated with various conditions. This review will explore the History, Mechanism of action, Pharmacological profile, efficacy, safety, drug interactions, indications. The review article discusses about the Polmacoxib analytical methods done in RP-HPLC, HPTLC and QbD. Polmacoxib has the potential to be utilized as a pain relief drug with diminished gastrointestinal side impacts compared to conventional nonsteroidal anti-inflammatory drugs for Osteoarthritis. Osteoarthritis (OA) is a persistent degenerative and incapacitating condition distinguished by intricate issues affecting the entire synovial joint. NSAIDs and available COX-2 inhibitors that are useful in osteoarthritis show limitations in terms of adverse effects. They all have black box warnings as they are not cardio, renal, and GI safe

Keywords: Polmacoxib, History, Osteoarthritis, Analytical methods.