EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

DRAWBACK OF CORTICOSTEROID TREATMENT AND SUBSEQUENT ALTERATION OF THE HEMATOLOGICAL PROFILES WITH HEPATIC TEXTURE IN RAT

†*M. M. R. Chowdhury, †Fahmida Afrin, S. S. Saha, Md. Ataur Rahman, Md. Ali Asgar, D. Das, Md. Kamrul Islam

ABSTRACT

An investigation was conducted on the effect of two corticosteroid drugs such as dexamethasone (Oradexon®) and predinisolone (Deltasone®) on hematological profiles (blood glucose, absolute number of various granulocytes) and histopathology of liver in rats for a period of 60 days. A total of 25 apparently healthy rats were randomly divided into 5 groups and each group contained 5 rats. Group-A (control) and was given only basal ration. Other treatment groups (B, C, D and E) were given dexamethasone (Oradexon®, @ 0.5 mg/kg b.wt.) and predinsolone (Deltason @ 2 mg/kg b.wt.) mixed with drinking water. The blood glucose level was increased significantly (P<0.01) in all four treatment groups (B, C, D and E). Corticosteroid drugs did not alter the feed intake and water consumption in treated rats. All treated rats showed a significant (P<0.05 and P<0.01) decrease in bodyweight, where Oradexon @ decreased body weight very significantly (P<0.01) from day 30 to 60. Absolute count of Neutrophil increased significantly (P<0.01). On the other hand, absolute count of Lymphocyte and Eosinophil were decreased significantly (P<0.01). Grossly, Rats in group B and D showed slight congestion in the liver. Thigh muscles were atrophied in all treatment groups (B, C and D). Hemorrhage and ulceration were found in all the treated rats. Swollen joints and softening long bones were observed in group B, C and E.

Keywords: Dexamethasone, Prednisolone, Rat, Lymphocyte, Liver. Hepatocytes.


[Full Text Article]

INDEXING

NEWS & UPDATION

  • New Issue Published

    Its Our pleasure to inform you that, EJPMR 1 December 2021 Issue has been Published, Kindly check it on http://www.ejpmr.com/home/current_issues

  • EJPMR: DECEMBER ISSUE PUBLISHED

    DECEMBER Issue has been successfully launched on 1 December 2021.

  • EJPMR New Impact Factor

    Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from  5.804 to 6.222, due to high quality Publication at International Level

  • Index Copernicus Value

    EJPMR Received Index Copernicus Value 79.57, due to High Quality Publication in EJPMR at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Article are invited for publication in EJPMR Coming Issue

Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )