A REVIEW ARTICLE ON PULMONARY DRUG DELIVERY USING POLYMERIC NANOPARTICLES IN TREATMENT OF LUNG CANCER

Naushad Ahmad, Komal Pathania* and Dr. Bhartendu Sharma

ABSTRACT

Lung cancer accounts for a sizable portion of all cancer incidences, it poses a serious threat to world health. Chemotherapy is one of the conventional treatments that has negative effects. The use of nanoparticles in colloidal medication delivery has received a lot of attention lately. When properly constructed, nanoparticles can improve drug release and retention in the lungs and provide a variety of administration routes. Tobacco smoke and other toxins are the main causes of lung cancer, innovative therapeutic approaches are required. When used with traditional medications, nanoparticles reduce adverse effects and improve the effectiveness of treatment. With an emphasis on polymer-based nanoparticles and their advantages over other carriers, the research explores the various types of nanoparticles and their relationship to lung cancer. With a focus on inorganic, lipid-based, and polymeric nanoparticles, we explore the many kinds of nanoparticles utilized in the treatment of lung cancer in this thorough discussion. Gold-based magnetic nanoparticles exhibit special qualities for cancer detection and targeted treatment. Drug delivery relies heavily on liposomes due to their biocompatibility, while solid lipid nanoparticles provide a different colloidal system that is also highly biocompatible. The safety and effectiveness of polymeric nanoparticles, particularly those derived from biodegradable polymers, have led to their increased popularity. Additional options for cutting- edge cancer treatment are offered by hydrogels, nanocapsules, and nanospheres. Notwithstanding the enormous obstacles that lung cancer presents, developments in nanotechnology, especially with regard to polymer-based nanoparticles, present encouraging opportunities for better patient outcomes, decreased toxicity, and improved medication delivery. This paper offers a glimpse into the future of individualized and successful cancer treatments by shedding light on the changing field of nanoparticle-based therapeutics for lung cancer.

Keywords: AcDex—acetylated dextran; F108—poly(ethylene oxide)-blockpoly(propylene Oxide)-block-poly(ethylene oxide); NCs—nanocapsules; NPs—nanoparticles; PCL— poly(ecaprolactone);PEG—poly(ethylene glycol); PLA—poly(lactic acid); PLGA— poly(lactide-coglycolide) NPs