MICROWAVE ASSISTED SYNTHESIS OF BENZOTRIAZOLE DERIVATIVES AS POTENTIAL TO ANTI-MICROBIAL AGENTS

Athifa Firdous, D. Sandya, D. Vasudha, D. Prabhakar, *B. Laxmi Narsaiah

ABSTRACT

The current research shows a rapid, clean, and environmentally sustainable method of the microwave-assisted synthesis of benzotriazole derivatives. The use of microwave irradiation significantly enhanced reaction efficiency, offering a rapid, energy-efficient, and environmentally friendly alternative to conventional synthetic methods. Microwave conditions led to improved yields and reduced reaction times, demonstrating the advantages of green chemistry in heterocyclic synthesis. The synthesized benzotriazole derivatives were characterized using Fourier Transform Infrared Spectroscopy (FTIR), which confirmed the presence of characteristic functional groups such as N–H, C=N, and aromatic C–H stretches, validating the successful formation of the target compounds. Additionally, Thin Layer Chromatography (TLC) was employed to monitor the progress of the reactions and confirm the purity of the synthesized products, where distinct Rf values helped in differentiating between intermediates and final products.The antimicrobial screening of the synthesized compounds revealed promising results, with several derivatives showing significant activity against both Gram-positive and Gram-negative bacterial strains, as well as selected fungal pathogens. These findings support the hypothesis that structural modification of the benzotriazole nucleus can enhance biological activity and provide new leads for antimicrobial drug development. In conclusion, this study not only demonstrates the effectiveness of microwave-assisted synthesis for preparing benzotriazole derivatives, but also highlights the potential of these compounds as antimicrobial agents. The integration of analytical methods like FTIR and TLC further ensured the reliability and reproducibility of the synthesis process.

Keywords: Microwave assisted synthesis, Benzotriazole derivatives, anti-microbial agents.