FORMULATION AND EVALUATION KETOROLAC LOADED HYDROGEL FOR INFLAMMATION

Paras and Praveen Kumar*

ABSTRACT

This project is all about making and testing Ketorolac-loaded hydrogels for delivering drugs via the skin. We used a number of analytical methods, including as organoleptic evaluation, melting point analysis, solubility testing, UV-Visible spectrophotometry, and FTIR spectroscopy, to describe ketorolac, a strong non-steroidal anti-inflammatory medicine (NSAID). Carbopol-940 and guar gum were used as gelling agents to make eight distinct hydrogel formulations (F1–F8). We looked at these formulations' physical characteristics, pH, spreadability, extrudability, washability, viscosity, drug content, and drug release in vitro. Among all of them, formulation F4 had the best properties, with great homogeneity, spreadability, and drug release profile (98.74% at 30 minutes), which was very similar to the marketed formulation. Accelerated stability tests on F3 showed that it was physically and chemically stable for more than 90 days. The results imply that the manufactured Ketorolac-loaded hydrogels, especially F4, are a viable and reliable option for topical distribution with more therapeutic potential.

Keywords: Ketorolac, hydrogel formulation, topical drug delivery, Carbopol-940, guar gum, physicochemical evaluation, in vitro drug release, FTIR spectroscopy, UV-visible spectrophotometry.