EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

CYTOKINE GENE POLYMORPHISMS AND THEIR ASSOCIATION WITH ORAL SQUAMOUS CELL CARCINOMA (OSCC): A NORTH INDIAN STUDY

Maneesh Kumar Gupta, Nibha Sagar, Rajeev Pant and Monisha Banerjee*

ABSTRACT

Oral Squamous Cell Carcinoma (OSCC), the eighth most common cancer worldwide has several risk factors such as alcohol, tobacco and smoking. Oral cancer involves production of cytokines, growth factors and adhesion molecules which promote optimal growth conditions for cancerous cells. The present study was undertaken to evaluate association of cytokine gene polymorphisms with oral cancer. Genotyping of SNPs viz. IL-6-597G/A (rs1800797), TNF-α-308G/A (rs1800629), IL-1β-511C/T (rs16944) and IL-1RN Variable Number of Tandem Repeats (VNTR) in intron 2 was carried out in 140 healthy age/sex matched control subjects and 130 oral cancer patients by PCR-RFLP. Genotype and allele frequencies were calculated and statistically analyzed by chi-square (χ2) using SPSS (ver.21.0). Gene-gene interaction, pairwise linkage disequilibrium (LD) based on ‘D’ statistics and correlation coefficients (r2) of frequencies were analyzed using SHEsis (ver. Online). Genotypic frequencies of IL-6, IL-1β and IL-1RN and allelic frequency of IL-6 showed significant association with oral cancer in north Indian population (p<0.001). Therefore, genetic polymorphisms in associated genes can be used as markers to predict oral cancer susceptibility. Gene-gene interaction analysis showed that individuals with SNP combinations T G G I* and T G G II* of IL-1β-511 C/T, IL-6-597A/G, TNF-α-308G/A and IL-1RN polymorphisms increase the risk of OSCC upto 18.7 and 7.3 folds respectively in the study population. This is probably the first report from India showing the combinatorial effect of these gene polymorphisms and OSCC susceptibility. The study will help to predict individuals at risk of developing OSCC and will provide leads for other cancers as well.

Keywords: Oral Squamous Cell Carcinoma; OSCC; IL-6; TNF-?; IL-1?; IL-1RN; North Indian population.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia