FORMULATION AND EVALUATION OF ARGEMONE OCHROLEUCA EXTRACT CREAM NATURCEUTICAL DELIVERY SYSTEMS AS ANTIMICROBIAL AND WOUND HEALING ACTIVITY

Mahmoud Mahyoob Alburyhi*, Salwa M. Raweh, Mokhtar Abd-Hafiz Al-Ghorafi, Abdalwali Ahmed Saif, Maged Alwan Noman

ABSTRACT

Wounds affect a large number of patients and can seriously reduce the quality of life. The purpose of this study was designed to investigate the phytochemicals and evaluate the antimicrobial agent for wound healing activity of Argemone ochroleuca extracts also to formulate the most active extract as oil in water cream (O/W) and evaluate its wound healing activity. The herbal creams (O/W) were formulated from methanolic Argemone ochroleuca extract. Four formulations were prepared with various concentration of excipients. The pH, spreadability and stability of prepared base were investigated. The base B4 was found appropriate for the preparation of cream. Completely cream was evaluated for its physical, chemical and stability parameters. Therefore, formulation of methanolic extract into a suitable herbal cream was aimed. The pH of prepared cream was near to skin pH, and cream was homogeneous, non-greasy and easily removed after application. Also, the best formulation for cream selected which Confirmed all the requirement for quality control tests for product and Argemone ochroleuca have a potential effect of bioactive methanolic extract that can be used in management of bacterial infection and promote wound healing activity. It was concluded that the best formulation selected F1 (1%) and F2 (2%) were safe in respect to skin irritation and allergic sensitization and exhibited the desired proprieties of consistency, spreadability, physicochemical stability and appearance may make it cosmetically acceptable.

Keywords: Argemone ochroleuca, Cream Formulation, Antimicrobial agent, Wound Healing Activity, Nutraceutical Delivery Systems.