STUDIES ON EVALUATION OF EFFECT ON NOVEL EXCIPIENTS ON IN- VITRO DISSOLUTION, RHEOLOGY AND STABILITY OF OIL BASED SUSPENSION OF PROGESTERONE

Heena Patel*, Madhuri Redekar, Sheetal K. Kamble, Jayashree S. Patil and Geetanjali Patil

ABSTRACT

Progesterone is one of the most important hormone in our body and regulates numerous functions Extensive first pass metabolism of progesterone by liver limits its oral administration. Intramuscular administration improves absorption of progesterone but is uncomfortable, since daily injections may cause pain, inflammation and redness at the site of injection. There is need to find some other oily vehicle and suspending agent so that prepared formulation can have enhanced solubility, dissolution, bioavailability, stability and be devoid of allergenicity. Previous works in our laboratory have indicated that Moringa oil and Neusilin meets all the attributes as vehicle and suspending agent respectively. So there is need to compare performance of Moringa oil and Neusilin with other oils and novels excipients, so as to optimize best formula. Performance of each selected oil and novel excipient can be further explained by on the basis of molecular interactions using computational studies so as to establish solid background to practical findings.

Keywords: Progesterone, Moringa oil, Neusilin, Sesame Oil, in- vitro dissolution.