FORMULATION AND INVITRO EVALUATION OF COLON TARGETED DRUG DELIVERY OF MELOXICAM TABLETS
K. Sujitha*, V. T. Iswariya, Ramya Andol and A. Hari Om Prakash Rao
In the present research work sustained release matrix formulation of Meloxicam targeted to colon by using various
polymers developed. Meloxicam is a selective cyclooxygenase-2 inhibitor with pH-dependent solubility. To
achieve pH-independent drug release of meloxicam, pH modifying agents (buffering agents) were used. Colon
targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by
using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as enteric coating
polymers. The precompression blend of all formulations was subjected to various flow property tests and all the
formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were
subjected to various evaluation techniques. The tablets were passed all the tests.Among all the formulations F3
formulation was found to be optimized as it was retarded the drug release up to 12 hours and showed maximum of
98.69% drug release. It followed zero order kinetics mechanism.
Keywords: Meloxicam, Colon targeted drug delivery system, Ethyl cellulose, Eudragit L100, Eudragit S 100.
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