HIGH-RESOLUTION MASS SPECTROMETRIC PROFILING OF ACORUS CALAMUS: EXPLORING ITS NEUROPROTECTIVE PROPERTIES

Lahamge Gayatri Satish*, Siddharth Shankar and Dev Nath Singh Gautam

ABSTRACT

Neurological disorders are emerging as a major global health concern, leading to increased attention on neuroprotective agents for their potential in preventing or mitigating neuronal damage. Acorus calamus (Vacha), a traditional medicinal herb, has demonstrated promising neuroprotective effects in preclinical experiments. This study employs high-resolution mass spectroscopy (HRMS) to profile the constituents of Acorus calamus (Vacha), focusing on identifying compounds with neuroprotective activity. The study mainly focuses on seven compounds (Nicotinamide, Betaine, Tranexamic acid, Anthranilic acid, Syringic acid, Fraxetin, Trans-anethole) with neuroprotective activity, suggesting that Vacha can modulate oxidative stress, inflammation, and neurotransmitter systems. These bioactive compounds bolster antioxidative defence, alleviate neuroinflammation, and preserve neuronal integrity, emphasizing their therapeutic value in neurodegenerative diseases. Their synergistic actions contribute to cognitive resilience and neurological health, positioning Acorus calamus as a promising natural remedy. This study advances our knowledge of the molecular constituents of Acorus calamus (Vacha) and underscores its potential as a neuroprotective agent.

Keywords: HRMS, Neuro-protective, Anti-oxidant, Vacha, Nootropic.