MICROWAVE ASSISTED PVA-GRAFTED-LOCUST BEAN GUM AND ITS APPLICATION IN SUSTAINED RELEASE DRUG DELIVERY SYSTEM

Dr. Darakhshan Afreen Shaikh*, Momin Subura and Dr. Ganesh G. Tapadiya

ABSTRACT

Polymers are macromolecules with high relative molecular mass. Natural gums are biodegradable and renewable sources with negligible adverse effects on human being. Natural polymers, because of their similar macromolecular structure to tissues, offer the convenience of recognition from the biological system. This further leads to the avoidance of issues related to toxicity and stimulation of a chronic inflammatory reaction, as well as lack of recognition by cells, which are frequently provoked by many synthetic polymers. The aim of this study is to graft locust bean gum with poly-vinyl alcohol [PVA] as monomer using ceric ammonium nitrate as initiator by microwave radiation technique and compare their physico-chemical properties. The obtained copolymer was evaluated for (% G) grafting efficiency (% GE) and percentage conversion (%C). Further 23 randomized full factorial design with 03 factors were evaluated at 02 levels, high level (+1) and low level (-1). DSC results shows that shift and changes occur in the graph of grafted gum as compared to the native gum. XRD results of native gum and grafted gum shows that, increase in crystallinity as well as increase peak intensity is comparatively more in grafted gum, than native gum. The apparent growth of fungi in mineral salts agar medium (contains no carbon) proves that the carbon present in the grafted gum had been utilized by the fungi for its growth. Thus it can be concluded that poly vinyl alcohol grafted locust bean gum is biodegradable in nature and can be used in sustained release dosage form.

Keywords: Locust bean gum, PVA, microwave radiation technique, sustained release dosage form, ceric ammonium nitrate, Copolymer.