FORMULATION AND EVALUATION OF GEL CONTAINING MANGIFERA INDICA LEAVES EXTRACT FOR THE TREATMENT OF MOUTH ULCERS

Ms. Vishakha Ramkrushna Nagare*, Ms. Maheshwari Purushottam Kadlag, Ms. Rutuja Ashok Darekar, Mayuri Sanjay Darade, Dr. Avinash B. Darekar

ABSTRACT

The present study focuses on the formulation and evaluation of a topical gel incorporating Mangifera indica (mango) leaves extract for the treatment of mouth ulcers. Mangifera indica leaves are known for their anti-inflammatory, antimicrobial, and antioxidant properties, making them a promising natural remedy for oral lesions. Mouth ulcers are a common oral condition characterized by painful lesions that can significantly impact daily activities such as eating and speaking. In recent years, there has been growing interest in herbal remedies due to their safety, efficacy, and biocompatibility. Mangifera indica (mango) leaves are rich in bioactive compounds such as flavonoids, tannins, and phenolic acids, which exhibit anti-inflammatory, antimicrobial, and antioxidant properties-making them a promising candidate for oral ulcer therapy. This review aims to provide a comprehensive overview of the formulation and evaluation parameters for gels incorporating Mangifera indica leaf extract, with a focus on their therapeutic potential in treating mouth ulcers. the gel contains the main ingredients mango Leaves extract, & Carbopol 934 as a gelling agent and Propylene glycol as a co-solvent. Another ingredient Glycerin as a humectant, Propylene glycol as a solvent & stabilizer, Methyl paraben as a preservative, Sodium saccharin as a Sweetener, Sodium bicarbonate as pH adjuster & mint oil as cooling agent. The formulated gel was tested for different parameters such as physicochemical parameters (pH, viscosity, distribution ability, etc.) The gel is homogeneous mixture that shows the pH 6.8. This gel was stable at room temperature protected from any germs and thus safe for use on mouth sores. The gel was prepared using a carbopol-based formulation, and its physicochemical properties, including pH, viscosity, spreadability, and homogeneity, were systematically evaluated. Results demonstrated that the formulated gel exhibited desirable physicochemical characteristics and enhanced ulcer healing. These findings suggest that Mangifera indica leaves extract gel may serve as an effective and natural therapeutic option for the management of mouth ulcers.

Keywords: Mangifera indica, mouth ulcer, herbal gel, anti-inflammatory, antimicrobial, oral care.