FORMULATION AND EVALUATION OF DULOXETINE FLOATING MICROPHERES

Nenavath Santhosh*, Raviteja Viswanatham, Avinash Dundigalla and A. Yasodha

ABSTRACT

The aim of study was formulate and evaluate floating microspheres of highly water soluble drug Duloxetine HCl, using cellulose acetate and eudragit RS100 polymers. The microspheres were prepared by solvent evaporation method. The prepared microsphere showed good drug loading capacity and floating ability. The particle size was ranged between 50 μm to 200 μm depends on the drug polymer ratio. The SEM study revealed that microspheres were good spherical geometry and uniform size. FT- IR studies of drug loading microspheres showed no interaction of drug and polymers. The in vitro re- lease studies were performed in 900 ml of 0.1N HCl for 12 h using USP XXIV dissolution apparatus. Release studies showed that microspheres that able to release the drug in sustain manner. Selected for- mulations were subjected to kinetics studies and stability studies. The release kinetics studies showed that the release the first order diffusion control and n value obtain from Higuchi model showed the re- lease mechanism. Stability studies indicated that developed microspheres were stable and retain their pharmaceutical properties at room temperature and 40ºc/75% RH of one month.

Keywords: Venalfaxine, Eudragit, Dissolution.