A PROSPECTIVE AND OBSERVATIONAL STUDY ON RATIONAL USE OF PROTON PUMP INHIBITORS AND THEIR ECONOMIC BURDEN

Dr. Maria Nooreen*, Dr. Mohd Minaz Pasha*, Dr. Mahveen Zoha, Dr. Ahmed Ali, Dr. Neha Begum and Dr. Mohammed Abdul Aleem

ABSTRACT

The study aimed to evaluate the rational use of proton pump inhibitors and their crucial economic impact. A prospective observational study was performed on 102 in-patient wards at tertiary hospital. The handling of inpatient prescriptions was carried out and assessed to determine the prescribing pattern associated with it. The case sheets of the patients were reviewed for PPIs prescription and relevant data was taken Out of 102 patients Pantoprazole was prescribed in 92.1% patients, Rabeprazole in 5.2% patients, Esomeprazole in 2.1% patients. Most commonly prescribed ppi in the study was pantoprazole. Moving to dose prescribed, out of 102 patients, 6 were prescribed with optimal dose of ppi and 96 patients were prescribed with higher dose of ppi. The PPI usage for off-label indication was identified as 34.3%, whereas as16.6% were having indications. Further, the prevalence of Non-Indicated Prescriptions of PPIs was determined to be 49.01%. A high proportion of non-indicated PPI use results in a high economic burden. This burden regarding percentage is 3.4% /patient. The outcomes demonstrate the challenges of PPI use was accompanied by unapproved indications, frequent inappropriate co-prescription with GCs and excessive dosages. Efforts should be paid to promote rational use and guarantee the decision of appropriate PPI therapy in the future. High proportion i.e., 49.1% of PPI non-indicated use was seen in high economic burden.353.9 is the cost burden observed /patient/hospitalization Hence, the use of PPI without a proper indication was the most common type of non-indicated use observed in the study.

Keywords: Proton Pump Inhibitors, Rabeprazole, Pantoprazole, esomeprazole, Cost Economic Analysis (CEA).