FORMULATION, DEVELOPMENT AND EVALUATION OF DORZOLAMIDE HYDROCHLORIDE NANOPARTICLES

*Varanasi Alekhya, M. Pallavi, Dr. Avinash Dundigalla and Dr. A. Yasodha

ABSTRACT

The goal of this study was to assess the efficacy of a method based on the creation of polymeric nanoparticles as an innovative formulation of Dorzolamide hydrochloride with enhanced therapeutic efficacy. Dorzolamide hydrochloride has low solubility and permeability, which result in limited and variable bioavailability; its low stability makes it difficult to develop stable aqueous liquid formulations. The Dorzolamide hydrochloride Polymeric nanoparticles were created using the solvent evaporation process. The numerous formulations with varied drug-polymer and surfactant ratios were analyzed and improved. Dorzolamide hydrochloride Polymeric nanoparticles containing PLGA were created using the solvent evaporation method, then the particle size was decreased by sonication. Particle size, surface morphology by SEM, drug excipient compatibility by FTIR, and in-vitro drug release experiments were used to characterize the produced nanoparticles. The formulation with the best encapsulation efficiency was (F-3) A drug encapsulation effectiveness of up to 92.85 % has been attained in this study. It was discovered that the efficiency of encapsulation improved along with the polymer content. According to the results of the current investigation, the manufacture of Dorzolamide hydrochloride Polymeric nanoparticles can be done using a solvent evaporation process followed by sonication.

Keywords: Dorzolamide hydrochloride drug, Polymeric Nano Particles, Solvent Evaporation, lipid, FTIR, invitro drug release.