COMPARATIVE EVALUATION OF CIPROFLOXACIN HYDROCHLORIDE LOADED NANOPARTICLES USING NATURAL, SYNTHETIC AND SEMI-SYNTHETIC POLYMERS

Ganesh N. S.*, J. Adlin Jino Nesalin, Risha Jahana, Reinhard David and Vineeth Chandy

ABSTRACT

The present study was undertaken with an aim to formulate and comparatively evaluate Ciprofloxacin hydrochloride loaded nanoparticles using natural, synthetic and semi-synthetic polymers. Nanoparticles were prepared by Nanoprecipitation technique using natural (chitosan), synthetic (PVA) and semi-synthetic (HPMC) polymers and its combinations. The influence of the polymer and combination of polymers was demonstrated. From the FTIR studies, the drug- polymer compatibility was confirmed. Evaluation studies like percentage yield, particle size, entrapment efficiency, drug content, and in-vitro dissolution study for formulations were performed. The drug entrapment efficiency was found to be in range of 41.3±0.12 - 83.56±0.25%. The drug content was found to be in the range of 48.59±0.17 - 87.44±0.30%. In-vitro drug release varied from 60.11 - 94.84%. The optimized formulation (F10) was further evaluated for SEM, FTIR studies and zeta potential. The optimized formulation (F10) showed good in-vitro drug release of 94.84% release at the end of 6th hour. From this study it could be concluded that the nanoparticles formulated using a combination of synthetic and semi-synthetic polymers by nanoprecipitation technique showed good entrapment efficiency, drug content and drug release.

Keywords: Nanoparticles, Ciprofloxacin hydrochloride, Polyvinyl alcohol (PVA), Hydroxypropyl methylcellulose (HPMC), Nanoprecipitation.