UNLOCKING THE LIPID-LOWERING POWER OF PIMPINELLA ANISUM: A NATURAL THERAPEUTIC APPROACH

Shwetha Kumari C. K.*

ABSTRACT

The purpose of this study was to assess the antihyperlipidimic properties of Pimpinella anisum L. aqueous extract against hyperlipidemia produced by Triton-X 100 and high-fat diets (HFD). The animals in both experimental models were split up into five groups of six. Chronic Acute hyperlipidemia was brought on by a single intraperitoneal injection of Triton-X 100 for seven days, and hyperlipidemia was brought on by feeding HFD once daily for 28 days. Using histopathological analysis to support the findings, the degree of protection against hyperlipidemia was assessed by measuring the levels of various lipid profiles, including triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and very low density lipoprotein (VLDL). Preventive P. anisum medication (1/2 gm/kg) dramatically decreased hyperlipidemia by raising HDL and lowering blood LDL, VLDL, TG, and TC. The histological alterations in the liver in both hyperlipidemia experimental animals corroborated the findings.

Keywords: Antihyperlipidemia, Pimpinella anisum L., High fat diet, Triton X- 100, Atorvastatin, TC, TG, LDL, HDL, VLDL.