ANTICANCER POTENTIAL OF 1,3,4 THIADIAZOLE AMIDE DERIVATIVES: A MEDICINAL CHEMISTRY PERSPECTIVE

Akash S. Gondkar and Girish A. Hampannavar*

ABSTRACT

1,3,4 thiadiazole amide, heterocyclic ring system bearing nitrogen and sulfur heteroatoms along with an amide
portion attached at C 3 position has attracted considerable interest in bioorganic and medicinal chemistry research
due to its remarkable anticanc er potential. This review unveils comprehensive exploration of their synthetic routes
and anticancer efficacy, highlighting key structural modifications within the 1,3,4 thiadiazole amide core. Their
efficacy against diverse anticancer targets including ki nases, tubulin, and specific cancer cell lines is critically
discussed. By focusing on the anticancer potential of 1,3,4 thiadiazole amides, this review aims to offer valuable
insights for the design of novel and effective anticancer therapies, covering re ports from the year 2005.

Keywords: 1,3,4 Thiadiazole Amide; Anticancer agents; Structure activity relationship (SAR); Cytotoxicity; Tumor inhibition.