EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

FETOMATERNAL OUTCOME IN MATERNAL HYPOTHYROIDISM COMPLICATING PREGNANCIES AT RIMS: A PROSPECTIVE STUDY.

M.S. Rajalakshmi, P.G. Trainee, Y. Ajit Kumar Singh, Assisstant Professor, Sujit Das, P.G. Trainee, Samchetsabam Randhoni Devi Professor.

ABSTRACT

Objective: To analyze the fetomaternal outcome in maternal hypothyroidism complicating pregnancies at RIMS, Imphal. Study Design: We conducted a Prospective Study in the Department of Obstetrics and Gynaecology, RIMS, Imphal, Manipur. The study included 300 pregnant women attending antenatal clinic of Obstetrics and Gynecology, RIMS, Imphal between October 2013 to March 2015.The variables were age, parity, period of gestation, obstetrical history, haemoglobin of mother, Apgar score, birth weight etc. Data were analyzed by Chi-square test using SPSS Programme. Results: Among 300 selected women overt hypothyroid patients were 14 (4.7%) and subclinical hypothyroid patients were 286(95.3%). Threatened abortion, as a complication occurred in 10 patients (3.3%). In the 2nd trimester follow up 268 patients (92.3%) were compliant and in the third trimester 236 patients (78.7%) were compliant. 16(5.5%) Patients had pre eclampsia (overt hypothyroids were 2 and subclinical hypothyroids were 14). Preterm labour was found in 12 cases. Maternal complications like PPH were found in 48.1% of the patients, who were not compliant. Low birth weight is reported in 22.2% of respondents who were non compliant and only in 14.4% of who were compliant, P value (<0.05) is significant. In non compliant group, 74.1% of the neonates developed RDS compared to only 6.7% of the neonates in the compliant group. . NICU admissions contributed to 63% in the non compliant group compared to 0.8% in the other group. Neonatal thyroid screening was abnormal in 7.4% of non compliant group and nil in the other group. Conclusion: Our study proves significant association between uncontrolled hypothyroidism and adverse fetomaternal outcome The pregnancy outcome observed in our subjects (compliant) was better. There was very low incidence of still birth, preterm deliveries, deaths etc. This might have been due to the thyroid hormones of mother which were maintained within the reference range.

Keywords: haemoglobin, fetomaternal, hypothyroids.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )