EVALUATION OF EFFECT OF ANETHUM GRAVEOLENS (SOWA) IN ALCOHOL WITHDRAWAL SYNDROME IN RATS

Sona B. Talreja*, Dr. Abhijit V. Shrirao, Dr. Deepak S. Mohale, Dr. Nitin I. Kochar and
Prof. Dr. A. V. Chandewar

ABSTRACT

Objective: To evaluate the effect of Anethum graveolense (Dill sowa) on: anxiety, analgesic activity and muscles strength in Alcohol Withdrawal Syndrome in rats. Methods: Liquid diet with ethanol was administered to the rats for 21 d. The rats in the control group were given sucrose as a liquid diet that provided the same number of calories. After alcohol withdrawal, rats were examined at 6th and 24th hour for major withdrawal signs that included anxiety, analgesic and muscles strength activity. Ethanol withdrawan anxiety was tested using elevated plus maze, light and dark apparatus, analgesic activity tested using tail flick apparatus and muscles strength was tested using rota rod apparatus. Anethum graveolens sowa extract (150 and 300 mg/kg, oral) and diazepam (2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Medication was administered 30 minutes prior to the 6 and 24 hr after Alcohol withdrwal. Results: Findings from the present study revealed that Anethum graveolens sowa extract treatment at doses 150 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. Conclusions: Anethum graveolens seems to be an active drug for the treatment of alcohol withdrawal syndrome.

Keywords: Anethum graveolens, Alcohol withdrawal syndrome, Diazepam, Anxiety, Analgesic, Muscles strength, Elevated plus maze, Light and dark,Tail flick, Rota rod apparatus.