EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

MUCUNA PRURIENS SHOWS NEUROPROTECTIVE EFFECT BY INHIBITING APOPTOTIC PATHWAYS OF DOPAMINERGIC NEURONS IN THE PARAQUAT MOUSE MODEL OF PARKINSONISM

Satyndra Kumar Yadav, Sachchida Nand Rai and Surya Pratap Singh

ABSTRACT

The neuroprotective effects of an ethanolic extract of Mucuna pruriens (Mp) seeds were evaluated in a Parkinsonian mice model induced by the pesticide paraquat (PQ). PQ induces classical symptoms of Parkinson’s disease (PD) including motor deficits, cellular loss in the substantia nigra (SN) and depletion of dopamine levels. The present study investigates the mechanisms of neuroprotection elicited by Mp, a herb traditionally recognized by the Indian system of medicine, Ayurveda. Co-treatment of PQ-treated mice with Mp significantly enhanced antioxidant activity and decreased oxidant levels. Mp also improved the motor abnormalities observed in PD mice, effectively rescued the levels of dopamine and its metabolites in the SN. HPTLC analysis of the Mp seed extract identified that a large proportion of the extract consisted of L-DOPA and also identified a novel constituent, ursolic acid, present in significant quantity. Mp also facilitated neuroprotection by creating an anti-apoptotic environment indicated by reduced apoptotic (Bax and caspase-3) and increased levels the anti-apoptotic (Bcl2) protein expression, respectively. Altogether, the present study suggests that Mp treatment provides nigrostriatal dopaminergic neuroprotection against PQ induced Parkinsonism by the modulation of oxidative stress and apoptotic machinery possibly accounting for the behavioural effects.

Keywords: Mucuna pruriens, ursolic acid, Parkinson’s disease, Bax, Bcl2, caspase-3.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia